June 2016 Edition

IJASR Volume 4 – Issue 2, June 2016 Edition

All listed papers are published after full consent of respective author or co-author(s).
For any discussion on research subject or research matter, the reader should directly contact to undersigned authors.

Determining the insulin resistance rate in Polycystic Ovary Syndrome patients (PCOs)

Ashraf  Olabi , Ghena  Alqotini


Background: Polycystic ovarian syndrome is the most common endocrine disorder of reproductive-age women.   Object: to detect Insulin resistance rate among PCOs patients in AUHOG .during May 2014 to December 2015.

Study design: Prospective Observational case-control Study. Materials and methods: Patients included in the study are PCOs patients that are diagnosed according to Rotterdam Criteria 2003 after excluding the co-morbidities. We compare the results with women had the same age and weight. Study method is based on: Fasting glucose and fasting insulin as well as Oral Glucose tolerance test. Results: our results demonstrated that 60% of the patients were obese with BMI more than 25 kg/m2. Clinically: Signs and symptoms of hyper-androgenism: 77 % of patients suffer from Hirsutism, whereas 60% suffer from Obesity. Laboratory finding: 12 cases had elevated   testosterone levels. Fasting glucose was abnormal in18% compared with 4% in controls. OGTT test was abnormal in 6% compared with3% in controls. Fasting insulin was above 20 IU/ml in (16%) compared with 4% in controls (P<0.05). Patients who   G/I ratio was below 4.5 were (13%). compared with 1% in controls. Insulin resistance according to G/I ratio at cut off value of 4.5 was 13% (P<0.05).

Conclusion: Insulin resistance was existed only in 18%patients of PCOs. Comparison with 4%in control study, so there is no evidence to use Insulin-Sensitizing Agents in treatment patients.

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Awareness of Osteoporosis among Al-Ahsa Population, KSA

Abdullah K. Al Bahrani, Mohammed S. Alhassan, Anas M. Altahir, Mukhtar A. Alalawi, Sami A. Alali, Tareq A. Al Mazeedi, Abdullah A. Al Sayafi, Mohammed S. Alsaeed, Mahdi  Alhajjimohammed, Batool Y. Alahmed .


Background: Osteoporosis is a serious silent disease that develops slowly over so many years and often diagnosed after the fragility fracture happened. Developing this disease depends on many factors like genetic predisposition, aging, dietary habits, physical activity, endocrine changes, lifestyles, general health condition and using medications.

 Aim: To assess the level of awareness of our subjects (aged 40 years and more) about osteoporosis and its risk and protective factors.

Methods: An in-public places designed questionnaire, and carried out in Al-Ahsa Governorate during January 2016. The targeted group was 345 randomly selected people aged 40 years and above. The pre-designed questionnaire consisted of 27 questions. Questions were on socio-demographics, knowledge on osteoporosis (occurrence, signs and symptoms, family history, risk factors, prevention, best screening age and the relationship of osteoporosis with the consumed milk and dairy products, soft drink, physical activity and smoking habits).

Results: Only 11% of the participants did not know about osteoporosis before.  8.12% has been diagnosed with osteoporosis most of them were female (75%). Less than one fifth of our sample (17.68%) knows that osteoporosis is a silent disease. Unsurprising, due to Al-Ahsa people life style where there is lake of regular activity (only 29.6% of the subjects practice sports activity regularly), the mean BMI is high (29.2 kg/m2).  Only 2.3% of the subjects were aware of the proper time for screening for osteoporosis. Most of the participants usually take their medical knowledge from either the internet or treating physician. Conclusions: The level of awareness about osteoporosis in our community does not guarantee a patient will practice good bone health behavior.

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Undiagnosed Chronic Myelogenous Leukemia Presented By Priapism

Waleed Almaeena and Shahirah Azzuz

Abstract:Priapism  is a potentially painful medical condition in which the erect penis does not return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours. Priapism is considered a medical emergency. The causative mechanisms are poorly understood but involve complex neurological and vascular factors. Priapism may be associated with haematological  disorders, especially sickle-cell disease, sickle-cell trait, and other conditions such as leukemia, thalassemia and Fabry’s disease, and neurologic disorders such as spinal cord lesions and spinal cord trauma .Priaspism is complication rarely seen in leukemia.In this case report we present a rare case of leukemia with rare presentation.

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Management of Premature Rupture of Membranes

Ashraf Olabi and Lucy Shikh Mousa


Context: review and compare the latent period, maternal, and neonatal morbidity and mortality in patient with premature rupture of membranes (PROM) managed expectantly either with prophylactic antibiotic or without.

Objective: to determine if antibiotic treatment during expectant management of PROM will reduce maternal and infant morbidity and if it will prolong pregnancy. Design: analytical statistical prospective case – control study. Setting: Aleppo university hospital, department of Obstetrics and Gynecology, Syria.. Patients: a total of 80 pregnant women > 28 weeks gestations with PROM were divided into 2 groups:  Case group: patients with PROM managed expectantly with prophylactic antibiotics. Control group: patients with PROM managed expectantly without prophylactic antibiotics.

Intervention : Intravenous ampicillin (2-g dose every 6 hours) for 48 hours followed by oral amoxicillin 500 mg dose every 8 hours orally for five days , plus one dose of azithromycine 1g at admition .

Main outcome measures: Maternal outcome: maternal infectious morbidity such as chorioamnionitis, postpartum metritis and surgical wound infections. Neonatal outcome : birth weight, Apgar scores, ventilation assistance, rates of respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC) ,neonatal infectious morbidity including ( sepsis , pneumonia ,meningitis ), and neonatal mortality.Median latent period. Results:  Median latent period in the study group was significantly longer than in the control group P=0.044. Maternal infectious morbidity was comparable between groups P=0.14. Neonatal infectious morbidity was significantly lesser in study group P=0.02. Conclusion:  we recommend that women with PROM with expectant management should receive prophylactic antibiotics to reduce infant and maternal morbidity and prolong latent period.

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Development of an analytical method for determining vitamin C by HPLC and its applIcation to citrus


ABSTRACT: HPLC method was developed and applied to the determination of Ascorbic acid (vitamin C) by separating Ascorbic acid from Citric acid interfering considerably with it, in Syrian Citrus fruits, in both Pulp and Peels. This study was applied on several Syrian fruits as: (Citrus sinesis (Navel, Jaffa), Grapefruit (Citrus paradisi) (ruby red-duncan), Citrus limon (Eureka-Hybrid), Citrus aurantium, Citrus reticulate (Clementine-Satsuma)) purchased from Aleppo markets. The maximum RDS% were not exceeded to 4.52% for all samples and 3.64% for the standards, with LOQ 0.942 and LOD 0.311. High performance liquid chromatography with UV-Vis detection were employed. The developed chromatographic method employed an C18 RP-column with dimension (250 x 4.6 mm; 5 µm). The diluted solution consists of buffer Na2HPO4 and NaH2PO4 with PH=2.5, adjusted by ortho-Phosphoric acid. The mobile phase was to be (methanol: water) HPLC grade with volume percentage (10:90) at PH =2.1, adjusting also by ortho- Phosphoric acid.

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Thaumatin is similar to water in blood glucose response in Wistar rats

Warid Khayata, Ahmad Kamri, Rasha Alsaleh

ABSTRACT: The aim of this study was to investigate the effect of thaumatin; a sweet tasting protein, compared to a natural sweetener; sucrose and a synthetic one; aspartame on blood glucose level and body weight in male Wistar rats. Sucrose, aspartame, and thaumatin solutions have been administrated orally every day to adult male Wistar rats for 8 consecutive weeks. Within this period, blood glucose was monitored during two hours and body weight was measured every two weeks. It was found that compared to water, aspartame and thaumatin did not elevate blood glucose at all. Also, neither aspartame nor thaumatin affected body weight. Subsequently, thaumatin can be considered as a safer and healthier sweetener than aspartame or sucrose, because it is natural and do not cause elevating in blood glucose.

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Postural Disorders in Patients with Hip Implants

Bekim Mulgeci, Enzo Ruberti, Gennaro Rocco 

ABSTRACT: The use of prosthetic devices has revolutionized the treatment of disabling conditions such as osteoarthritis and rheumatoid arthritis. By failing to assess the full importance of physical therapy, some patients who underwent successful hip replacement surgery reported complications because surgery was not followed up by proper course of physiotherapy treatment. Patients need to become better aware of their condition and follow through with post-operative care. In recent years, technology has developed numerous prosthetic models inspired by different mechanical and biological principles, so as to better reproduce the articular physiology. Hip replacement surgery has a better chance of success in function and in patient satisfaction if accompanied by post-operative rehabilitation. In our study, rehabilitation was carried out according to specific objectives, followed by a series of successive stages followed, depending on the type of surgery performed and the patient’s prosthetic. The rehabilitation plan in our study successfully ensured that patients could listent to their bodies, becoming more aware of them by providing patients with the information and tools to be able to intervene in case of pain and functional limitations.

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