June 2015 Edition

IJASR Volume 3- Issue 2, June 2015 Edition

All listed papers are published after full consent of respective author or co-author(s).
For any discussion on research subject or research matter, the reader should directly contact to undersigned authors.

Selective Spectrofluorimetric method for the Determination of Valacyclovir in bulk and tablets through Derivatization with O- Phthalaldehyde in presence of 3-Mercaptopropionic Acid

Amir Al-Haj Sakur, Hanan Fael

ABSTRACT: A new, selective and sensitive spectrofluorimetric method was developed and validated for the determination of valacyclovir via derivatization with o-phthalaldehyde in presence of 3-mercaptopropionic acid in alkaline medium. The resulted derivative has a strong blue fluorescence that was measured at 452 nm after excitation at 336 nm in aqueous solution. The reaction conditions were carefully studied and optimized. Under the optimum conditions, the fluorescence intensity was linear over a concentration range of 0.40 – 2.00 µg/mL (R2 = 0.9998) with a detection limit of 0.020 µg/mL. The proposed method was fully validated and effectively applied to the analysis of valacyclovir in pure form and tablets. Statistical comparison of the results obtained by the proposed and reference method revealed no significant difference in the performance of the two methods regarding the accuracy and precision respectively. A proposal for the reaction pathway with o-phthalaldehyde was postulated.

[Download]                                                                                                  PP 01-10


Effects of Garlic Supplementation on Fasting Blood Sugar, HbA1c and Lipid Profile in Type 2 Diabetics Receiving Metformin and Glyburide

Rafah Manafikhi, Louma Kalie, Raghda Lahdo

ABSTRACT: Diabetes mellitus is a metabolic disorder characterized by failure of glucose homeostasis with

disturbances of carbohydrate, fat and protein metabolism caused by defects in insulin secretion, insulin action, or both. The aim of this study was to evaluate the effects of  natural substances such as garlic on fasting blood sugar, HbA1c and lipid profile in patients with type 2 diabetes who were treated with metformin and glyburide. The study lasted for 12 weeks, the patients (n = 96) were divided into 2 groups. Group G (n = 51) was given garlic capsules at a dose of 50 mg/day in combination with their treatment. While, group C received their treatment alone (n = 45). We measured fasting blood sugar (FBS), Glycated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) at the beginning of the study (week 0) and at the end of the study (week 12). Our results showed a decrease in fasting blood glucose in garlic group when compared from week 0 to week 12, but this reduction was statistically insignificant and no significant change in HbA1c was observed. On the other hand, there was a significant decrease in TG levels in garlic group at week 12 in comparison with the baseline values at week 0. There was also a decrease in TC and LDL-C levels from week 0 to week 12 in garlic group, but this reduction was statistically not significant. While, no significant change in HDL-C levels was observed.

Conclusively, the combination of garlic with antidiabetic agents (metformin and glyburide) has shown hypoglycemic and hypolipidemic effects. So garlic may be a good addition in the management of patients with type 2 diabetes.

[Download]                                                                                                   PP 11-18


Enhancing the safety culture in Albanian healthcare institutions

Jasemin Todri, Enkeleda Gjini

ABSTRACT: Being that the safety culture is still a novelty for Albanian healthcare institutions this article explores different experimental Enterprise Risk Management approaches appropriate to healthcare risk managers aiming to enhance the safety culture in them. First of all for, a precise definition related to risk incidents, errors in medicine and near-misses is given. And correspondently, healthcare risk managers are advised to establish a proactive risk management framework configured in gap analysis related to circumstances that generate errors and violations, human risks and technology to accurately organize the above mentioned process, make managerial decisions and create a business culture oriented toward safety through the exploitation of bottom-up service lines.  Undoubtedly, that these framework is expensive not so much for the concept idea proposed than for staff hiring and continuous training, developing “system-wide” policies and procedures, internally managing the information received by offering also good opportunities in medicaltourism being that experience and costs become two key points for further development of these institutions in the near future.

[Download]                                                                                                     PP 19-25


Selective Spectrofluorimetric Method for the Determination of Perindopril Erbumine in Bulk and Tablets through Derivatization with O-Phthalaldehyde in Presence of 3Mercaptopropionic Acid

Amir Al-Haj Sakur, Tamim Chalati, Hanan Fael

ABSTRACT: A new, selective and sensitive spectrofluorimetric method was developed and validated for the determination of perindopril erbumine via derivatization with o-phthalaldehyde in presence of 3mercaptopropionic acid in alkaline medium. The resulted derivative has a strong blue fluorescence that was measured at 452 nm after excitation at 340 nm in aqueous solution. The reaction conditions were carefully studied and optimized. Under the optimum conditions, the fluorescence intensity was linear over a concentration range of 1.2 – 8.4 µg/mL (R2 = 0.9997) with a detection limit of 0.097µg/mL. The proposed method was fully validated and successfully applied to the analysis of perindopril erbumine in pure form and tablets. Statistical comparison of the results obtained by the proposed and reference method revealed no significant difference in the performance of the two methods regarding the accuracy and precision respectively. A proposal for the reaction pathway with o-phthalaldehyde was postulated.

[Download]                                                                                                       PP 26-37


First Line in Shakespeare’s Plays; Technique and Meaning

Mohamad Haj Mohamad

ABSTRACT: Giving readers the first initial attraction into the text looks a mandatory prerequisite in literature. The first few words, as expected, should galvanize attention and create the first impact on the reader and prepare for the following lines. The introductory speech is expected to brief readers and audience about the yet to unfold plot. The first line is supposed to lead readers into the atmosphere of the play and help them get wheeled into the events and above all, encapsulate, as much as possible, the tenure of the play by giving the preliminary dose supposed to form an embryonic of yet to cluster understanding of events or in other words try to offer a platform to weave a gradual crystallization of the nature of characters. Again the first line is supposed to help put the course of events on the expected track to make the best approach possible to the play. In Shakespeare’s plays, first lines are mostly telling because they key in events, characters and the plot itself with meticulous and careful choice of words.

[Download]                                                                                                       PP 38-46


Seasonality comparison between simulated and measured wind field: case study of Tunisian arid areas

Mohamed Labiadh

ABSTRACT: The absence of pre-established input meteorological database is one of constraint to apply modeling tools to simulate the desert emissions on a continental scale. Different meteorological models are used to provide the surface wind fields. The purpose of this work is the simulation at finer spatial and temporal scales, from a meteorological model “Regional Atmospheric Modeling System (RAMS)”, the surface wind speed in Tunisian arid zones. To evaluate the consistency of wind field simulated by RAMS in southern Tunisia, we compared the wind speeds at 10 meters simulated by RAMS and measured by 2 meteorological stations located in the study area which are Djerba (costal station) and Tozeur (inland). A very good correlation between measured and calculated wind fields was found. In addition, a very good agreement is observed, in particular with respect the seasonality of wind speeds, with a maximum recorded in spring and a minimum marked in summer.

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Evaluation of Fructosamine and Ischemia–Modified Albumin as prognostic markers for cardiovascular disorders in type 2 diabetic patients

Jehan Al KRITA, Mohamad Sami JOHA, Ali IBRAHEEM

ABSTRACT Cardiovascular disorders (CVD) are a major complication of diabetes mellitus. They have always been underestimated in patients with diabetes. Therefore, a delayed recognition of various forms of CVD worsens the survival prognosis for many diabetic patients. In this study, we assessed Ischemia-modified albumin (IMA) and Fructosamine  as prognostic markers for CVD in Type 2 Diabetic Patients (T2DP).  In contrast to Fructosamine, There was a significant difference (p <0.0001) between levels of IMA in diabetic patient with CVD as compared with those without CVD. No correlation has been found between Fructosamine and IMA in T2DP with CVD (r = -0.169, p = 0.245).  For IMA, We proposed a calculated Cutoff to predict T2DP who may sufferer of CVD.

[Download]                                                                                                     PP 52-56