IJASR Volume 5 – Issue 2, August – September 2017 Edition
All listed papers are published after full consent of respective author or co-author(s).
For any discussion on research subject or research matter, the reader should directly contact to undersigned authors.
LIFE QUALITY OF PATIENTS SUFFERING CEREBRAL STROKE
Sidita Haxholli, Caterina Gruosso, Gennaro Rocco, Enzo Ruberti
BACKGROUND: A cerebral stroke occurs when the brain’s blood supply is either interrupted or reduced. When it happens, the brain does not get enough oxygen or nutrients, causing brain cell dysfunction or death . Cerebral Stroke in the majority of cases is a serious cerebro-vascular event that causes, if not leading directly to death, a devastating psycho-physical impact on the affected patient, consequently this patient is destined to die or suffer a qualitative health living. About 35-40% of those who survived by a Stroke report a serious disability, while almost 50-60% have less limitations but still are affected by a normal functioning on regard to daily life activities. Amongst them, 30%show spasticity or flaccidity of the limbs, depression, cognitive impoverishment, disorientation, pain, malnutrition and sleep disturbances, as well as disability to express their own needs or feelings. OBJECTIVES: The objective of this study is to evaluate the quality of life among adults suffering troke effects and analyze the socio-demographic, clinical and functional factors that influenced the different areas of QOL of these patients.METHODS: The study is a cross-sectional study conducted of data results of three questionnaires, (asked 60 patients suffering a Stroke Unit in Tirana – Albania) which successfully fulfilled inclusive and exclusive criteria of this study. RESULTS: Female patients were n = 32; male n = 28. The socio- demographic and clinical characteristics of the study population are the following: Average age is 68.17 years old (± 10.68), and the time elapsed since the lesion is predominantly within 6.2 months (± 17.43). Amongst the types of stroke, the most predominant was ischemic stroke (61.67%). As well as (58.33%) of patients were involved in a post-stroke rehab procedure for 1-6 months of treatment. Multivariate regression analysis showed that patients with a lower duration of Stroke lesion but who were younger and more independent had better QOL than physical functioning. CONCLUSIONS: Research has led to consider beyond the aspects of physical health and cognitive functioning, psychic aspects, as well as psychological deterioration which can be highly important in terms of perception of satisfaction of one’s life by the respondents.
ANALYTICAL SPECTROPHOTOMETRIC STUDY OF CANDESARTAN CILEXETIL IN TABLETS FORMULATIONS
HASSAN SEDDIK, MOUSTAFA ALABO JOUMAA
ABSTRACT: Spectrophotometric method was developed and applied for determination of Candesartan Cilexetil (CDC) in tablets formulations. This new method was applied for determination (CDC) in several Syrian trademark drugs. The proposed method is based on the formation of colored complex between
2, 6-Dichloroquinone chlorimide (DCQC) with CDC. Under optimized conditions, it shows a maximum absorption at 467nm. The analytical parameters and theirs effects are investigated. Beer’s law was obeyed in the range of 20 – 100 µg/mL, with correlation coefficient R2 = 0.9988. The average recovery of CDC was between 98.09 and 102.86%. The limit of detection (LOD) and limit of qualification (LOQ) were 2.49 and 7.55 µg/mL, respectively. The proposed method has been successfully applied to the analysis of the studied drug in pure form and pharmaceutical formulations.
The Needs of Mothers of Children with Autism Spectrum Disorder (ASD) in the Kingdom of Saudi Arabia (KSA): A Qualitative Study
Alyaa Hemdi, David Daley
Abstract: The purpose of this qualitative study was to explore the unmet needs and experiences of mothers Of ASD children in The Kingdom of Saudi Arabia (KSA). This study employed telephone interviews with eight Saudi mothers raising a child with autism. Questions from a researcher-developed interview guide elicited responses about challenges and unmet needs. Results indicated that the majority of respondents felt they had low to no knowledge of ASD prior to and after their child’s diagnosis. Six themes were identified: i) Mothers’ identification of their lack of information about their children with ASD, ii) Mother’s perceptions about their mental and physical well-being, iii) Mothers’ recognition of their constant challenges raising children with ASD,iv) Suggestions to increase public awareness about ASD, v) Mothers’ identification of their training needs, and vi) Mothers’ perceptions of their children’s educational needs . Respondents insisted that cultural issues such as lack of transportation and fathers’ involvement did add to their burden. This study recommended that professionals and academics in KSA should take into consideration the unmet needs of mothers of ASD children when designing interventions and services for children with ASD to ensure they are tailored to the cultural context and needs of mothers.
New electrochemical methods for the determination of Prasugrel using drug selective membranes
Mohammad Haroun, Dania Nashed, Amir Alhaj Sakur
ABSTRACT: Prasugrel ion selective electrodes were constructed from PVC matrix containing Prasugrel HCl and [ ammonium Reineckate (PRS-RNK )] or [ sodium Tungstate (PRS-TUN) as the sensing elements in presence of di-n-butyl phthalate (DBP) as the plasticizing solvent mediator. the best PVC membrane electrodes were made of 4% ion pair for both (PRS-RNK) and (PRS-TUN), 48% PVC , 48% DBP . the two electrodes showed a fast , stable and Nernstian response . the electrodes exhibit linear response over concentration range 10-6-10-2mol /l with Nernstian slope 59.08 or 55.09 for sensor 1 and sensor 2 respectively with detection limit (LOD ) 0.035µM-0.09µM and quantification limit (LOQ) 0.108 µM-0.3µM for sensor 1 and 2 respectively. the both electrodes were effective at pH range between 1-4 . the electrodes showed very good selectivity for Prasugrel in presence of different inorganic cations and pharmacological related compounds . the electrodes exhibited a fast dynamic response of (15± 2sec / 20±2 sec) for a period of 8 days/2days without significant change in electrode parameters , the methods are precise as shown by mean recoveries range of (98.8-101 %)– (97-102 %) with mean relative standard deviation less than 3.94 and 4.9% for sensor 1 and 2respectively. Prasugrel is determined successfully in pure and pharmaceutical preparations by this described methods.
Alyaa Hemdi, David Daley
Abstract: This meta-analysis (M-A) evaluated the effectiveness of parenting interventions on parental functioning in parents of children with autism spectrum disorder (ASD). Electronic searches of Pub Med, Psyc INFO, and Web of Knowledge databases identified controlled and pre to post trials evaluating the effectiveness of parenting interventions on parental functioning, Eleven studies that met the inclusion criteria were included in this M-A. A random effect M-A estimated pooled standard mean difference (SMD) for parenting interventions on measures of stress, sense of competence, parenting practices, depression and anxiety. Analyses revealed medium but significant effects of interventions on parents’ stress pre-post intervention. This effect remained medium and significant when controlled studies were analysed and also following sensitivity analyses removing non-randomised trials. Moreover, the analyses showed a large and significant effect of interventions on parental sense of competence pre-post intervention. The effect decreased to medium and significant for sense of competence when controlled studies were analysed and remained medium and significant after sensitivity analyses removing non-randomised trials.